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Big Data, Genes, and Medicine
by Isabelle Bichindaritz- 4.2
Approx. 40 hours to complete
RNA and Proteins...
Command Line Tools for Genomic Data Science
by Liliana Florea, PhD- 4.1
Approx. 12 hours to complete
Introduces to the commands that you need to manage and analyze directories, files, and large sets of genomic data. This is the fourth course in the Genomic Big Data Science Specialization from Johns Hopkins University. Basic Unix Commands Basic Unix Commands 1: Content Representation Basic Unix Commands 2: Files, Directories, Paths...
Metagenomics applied to surveillance of pathogens and antimicrobial resistance
by Ana Sofia Ribeiro Duarte , Tine Hald , Sünje Johanna Pamp , Patrick Munk , Liese Van Gompel , Valeria Bortolaia , Pimlapas Leekitcharoenphon- 4.7
Approx. 15 hours to complete
The field of metagenomics and whole community sequencing is a promising area to unravel the content of microbial communities and their relationship to disease and antimicrobial resistance in the human population. Bioinformatic tools are extremely important for making sense out of metagenomics data, by estimating the presence of pathogens and antimicrobial resistance determinants in complex samples....
COVID-19 - A clinical update
by Frederick S. Southwick, MD- 4.7
Approx. 12 hours to complete
As an expert in infectious diseases, editor of the Journal of Infectious Diseases and author of the textbook Infectious Diseases: A clinical short course, McGraw-Hill April 2020, I have been concerned about the misinformation being shared about the COVID-19 epidemic. How did this disease develop? Where did it come from? How does it cause diseases?...
Case Studies in Personalized Medicine
by Dan Roden, M.D.- 4.8
Approx. 18 hours to complete
Learn how advances in biomedicine hold the potential to revolutionize drug development, drug treatments, and disease prevention: where are we now, and what does the future hold? This course will present short primers in genetics and mechanisms underlying variability in drug responses. After completing this course, learners will understand 1. 2....
Genomics: Decoding the Universal Language of Life
by Dr. Gene E. Robinson- 4.6
Approx. 36 hours to complete
What is a genome? A genome contains all of the information that a cell needs to develop, function, and reproduce itself, and all the information needed for those cells to come together to form a person, plant, or animal. Professor Robinson is the main instructor for this course. In addition, each module features several guest instructors....
生物信息学: 导论与方法
by Ge Gao 高歌, Ph.D. , Liping Wei 魏丽萍, Ph.D.- 4.7
Approx. 26 hours to complete
欢迎选修北京大学MOOC课程“生物信息学:导论与方法”。 近三十年来,生命科学与计算科学飞速发展。生物信息学是一门生命科学与计算科学的前沿交叉学科。生物信息学产生和迅猛发展的主要推动力来自于新一代测序等高通量技术在生命科学领域越来越广泛的应用。目前,人和很多动植物的基因组已经被测序出来。已知DNA序列的数量已超过20兆亿碱基,每五个月翻一番。这些前所未有的大数据中蕴藏着很多尚不为人知的新发现、新知识,给生命科学研究带来新的历史机遇。但是同时,这些大数据不仅数量巨大、持续呈现指数增长的趋势,而且噪音高,异构程度高。准确、快速地分析这些数据需要先进的计算方法。 生物信息学是一门强大的新技术,是用来分析、存储、搜索海量生物医学数据的信息技术和计算技术。另一方面,生物信息学是一种研究生命科学问题的新方法、新思路,是一种从全基因组出发、从系统水平出发、基于数据整合,提出新假说、发现新规律的研究方法。在这门“生物信息学:导论与方法”网上课程中,我们将向您系统地讲授生物信息学主要概念及方法。课程内容从基础的序列比对开始,循序渐进,围绕深度测序数据分析、计算基因组学、分子通路鉴定等当前研究的前沿热点内容进行介绍与讨论。进一步地,我们会以我们实验室自己开发的算法、软件及数据库为例,告诉您如何开发新的生物信息学技术。我们将用具体实例展示给您,如何用生物信息学的方法及研究思路来解决生命科学里的实际问题。我们也邀请到几位生命科学领域资深教授介绍相关的生物信息学重要工作及生物信息学在生命科学中的作用。 本课程材料采用 CC BY-NC-SA 协议开放共享。 导论与历史 课程介绍 什么是生物信息学 生物信息学历史 中国大陆的生物信息学 阅读参考 讲义 导论与历史 序列比对 序列比对中的基本概念 利用动态规划进行全局比对 从全局比对到局部比对 考虑仿射空位罚分的序列比对,以及如何计算Needleman-Wunsch算法的时间复杂度 关于同源、相似性、相似性矩阵和点阵图 M. S. Waterman教授访谈 学生课堂报告(一) 学生课堂报告(二) 阅读参考 讲义 序列比对 序列数据库搜索 序列数据库 BLAST算法初探 学生课堂报告 阅读参考 讲义 序列数据库搜索 马尔可夫模型 从状态到马尔可夫链 隐马尔可夫模型 用隐马尔可夫模型建立预测模型 学生课堂报告(一) 学生课堂报告(二) 学生课堂报告(三) 学生实践 阅读参考 讲义 马尔可夫模型 新一代测序NGS:重测序的回帖和变异鉴定 新一代测序 序列回帖和变异鉴定 序列回帖和变异鉴定的分析演示...
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Epigenetic Control of Gene Expression
by Dr. Marnie BlewittTop Instructor- 4.8
Approx. 17 hours to complete
While the human genome sequence has transformed our understanding of human biology, it isn’t just the sequence of your DNA that matters, but also how you use it! How are some genes activated and others are silenced? How is this controlled? The answer is epigenetics. This course will give an introduction to the fundamentals of epigenetic control....
Chemical Biology
by Robbie Loewith , Marcus J. C. Long- 4.8
Approx. 21 hours to complete
RNA interference and genome editing...
Imagining Other Earths
by David Spergel- 4.7
Approx. 26 hours to complete
Are we alone? This course introduces core concepts in astronomy, biology, and planetary science that enable the student to speculate scientifically about this profound question and invent their own solar systems. All the features of this course are available for free. It does not offer a certificate upon completion. Introduction Welcome...