Course Summary
This course explores the field of personalized medicine and how it is revolutionizing healthcare through genomic technologies and individualized treatment plans.Key Learning Points
- Understand the principles and technologies behind personalized medicine
- Learn how to analyze genomic data and apply it to personalized treatments
- Explore case studies and real-world examples of personalized medicine in action
Related Topics for further study
Learning Outcomes
- Understand the principles and technologies behind personalized medicine
- Analyze genomic data and apply it to personalized treatments
- Evaluate the ethical implications of personalized medicine
Prerequisites or good to have knowledge before taking this course
- Basic knowledge of biology and genetics
- Familiarity with data analysis tools
Course Difficulty Level
IntermediateCourse Format
- Online
- Self-paced
Similar Courses
- Genomic Data Science
- Data Science in Healthcare
Related Education Paths
- Master of Science in Personalized Medicine (University of Southern California)
- Certificate in Precision Medicine (Johns Hopkins University)
Related Books
Description
Learn how advances in biomedicine hold the potential to revolutionize drug development, drug treatments, and disease prevention: where are we now, and what does the future hold? This course will present short primers in genetics and mechanisms underlying variability in drug responses. A series of case studies will be used to illustrate principles of how genetics are being brought to bear on refining diagnoses and on personalizing treatment in rare and common diseases. The ethical and operational issues around how to implement large scale genomic sequencing in clinical practice will be addressed.
Outline
- UNIT 1: INTRODUCTION TO PERSONALIZED MEDICINE
- A welcome message from Dr. Roden
- Introduction to Personalized Medicine
- Genetics Definitions, Part I
- Genetics Definitions, Part II & Types of Genetic Variants
- Data Analysis, Part I: What is a Good Study?
- Data Analysis, Part II: What is a Good Test?
- Introduction to Drug Therapy and General Mechanisms Underlying Variability in Drug Responses
- Variability in Drug Therapy
- Drug Metabolism & Transport
- Genetic Variability in Drug-Handling Molecules
- **Inside VUMC: The Promise of Personalized Medicine
- About this course
- Introduction to Personalized Medicine
- UNIT 2: STUDYING GENETIC VARIATION
- Family History and Inheritance Patterns
- Ancestry: Genetic Variation Across Generations and Geography
- Finding Disease-Associated Genes: Linkage
- **Inside VUMC: From Phenotype to Genotype and Back: Studying Heart Disease in Families
- Genome-Wide Association
- Sequencing
- **Inside VUMC: History of Sequencing Technologies
- Studying Genetic Variation
- UNIT 3: CASE STUDIES IN PERSONALIZED MEDICINE, PART 1
- From rare to common disease: familial hypercholesterolemia
- Using Genomics to Find New Drug Targets: Familial Hypercholesterolemia
- Muscle Pains During Statin Therapy (Myopathy)
- HLA-Mediated Immune Reactions (Skin Rash)
- Long QT Syndromes, Part 1
- Long QT Syndromes, Part 2
- **Inside VUMC: Studying Cardiac Arrhythmias in Cells
- A Second Heart Attack a Month After a First
- Headache During Venlafaxine (Antidepressant)
- Respiratory Arrest After Tonsillectomy
- A Bleeding Complication 5 Days After Starting Warfarin
- **Inside VUMC: Genotyping
- Drug Metabolism and Variable Drug Responses – Four More Examples
- Case Studies, Part I
- UNIT 4: CASE STUDIES IN PERSONALIZED MEDICINE, PART 2
- Cystic Fibrosis
- Marfan Syndrome
- A Case of Idiopathic Heart Failure
- Personalizing Care in Neuropsychiatric Disease
- Personalizing Care in Diabetes
- Genomics to Subtype Cancer
- A Family Member With Breast Cancer
- A Family Member With Colon Cancer
- **Inside VUMC: Organizing Infrastructure to Support Genetic Testing Decisions
- Case Studies, Part II
- UNIT 5: PERSONALIZED MEDICINE IN A SYSTEM OF CARE
- Where We Are Now
- Where We Are Going
- **Inside VUMC: Using iPSCs: Drug Discovery and Drug Efficacy
- **Inside VUMC: Generating iPSCs
- Electronic Medical Records & The Learning Healthcare System (Discovery)
- Using Electronic Records to Personalize Care (Delivery)
- **Inside VUMC: Using the EMR to Ascertain Patients for Genetic Studies
- **Inside VUMC: Biobanking & DNA Extraction at BioVU
- **Inside VUMC: Personalized Medicine is a Team Sport
- Personalized Medicine in a System of Care
- FINAL REFLECTION ACTIVITY
Summary of User Reviews
Key Aspect Users Liked About This Course
Many users found the personalized approach to medicine to be particularly valuable.Pros from User Reviews
- The course provides a comprehensive overview of personalized medicine
- The instructors are knowledgeable and engaging
- The course includes practical case studies that help students apply the concepts learned
Cons from User Reviews
- Some users found the course material to be too advanced
- The course requires a significant time commitment
- Some of the course content is repetitive
Dan Roden, M.D.
4.8 Raiting
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