Course Summary
This course provides an introduction to evidence-based toxicology and teaches students how to use scientific evidence to evaluate the potential toxicity of chemicals.Key Learning Points
- Learn how to evaluate the potential toxicity of chemicals using scientific evidence
- Understand the role of evidence-based toxicology in chemical regulation and risk assessment
- Explore the challenges and limitations of evidence-based toxicology
Related Topics for further study
Learning Outcomes
- Understand the principles of evidence-based toxicology
- Evaluate the potential toxicity of chemicals using scientific evidence
- Identify the challenges and limitations of evidence-based toxicology
Prerequisites or good to have knowledge before taking this course
- Basic knowledge of biology and chemistry
- Familiarity with scientific research methods
Course Difficulty Level
IntermediateCourse Format
- Online self-paced course
- Video lectures
- Quizzes and assignments
Similar Courses
- Environmental Toxicology
- Chemical Safety and Security
- Introduction to Environmental Science and Sustainability
Related Education Paths
Related Books
Description
Welcome to the Evidence-based Toxicology (EBT) course. In medicine and healthcare, evidence-based medicine has revolutionized the way that information is evaluated transparently and objectively. Over the past ten years, a movement in North America and Europe has attempted to translate this revolution to the field of toxicology.
Outline
- Introduction & Shortcomings of Current Approaches
- Welcome
- Introduction to the Course
- Introduction
- Shortcoming No. 1: Narrative Reviews
- Shortcoming No. 2: Bias in Reviews
- Shortcoming No. 3: Evidence Writing
- Shortcoming No. 4: External Validity
- Shortcoming No. 5: Assessing New Methods
- Shortcoming No. 6: Inadequate Reporting
- Letter to Learners
- Course Learning Objectives
- Supporting reading
- Practice Quiz 1
- History and Causation
- Welcome to Module 2
- Personal First Exposures to Evidence-Based Medicine
- The Start of EBT
- The First Conference 2007 to the Start of the EBT Collaboration 2011
- The Evidence-Based Toxicology Collaboration (EBTC)
- Introduction Causation vs. Correlation
- The Hill Principles of Epidemiology and their Relation to Toxicology
- The Problem of Causation in Toxicology
- Biomarker Concept in Mechanistic Toxicology
- Mechanistic Validation
- The Future of Causation in Complex Systems
- Supporting reading
- Supporting reading
- Practice Quiz 2
- Systematic Review and Meta-Analysis
- Welcome to Module 3
- Systematic Reviews: Definition and Principles
- Systematic Reviews - Protocol Development
- Systematic Reviews - Protocol Development (Part 2)
- History
- Meta-analysis Guidelines
- Meta-analysis Protocol, Part 1
- Meta-analysis Protocol, Part 2
- Supporting reading
- Supporting reading
- Practice Quiz 3
- Mid-course exam
- Risk of Bias & Application to Test Methods Comparison
- Welcome to Module 4
- Introduction to Risk of Bias Concept in Critical Appraisal of Studies
- Examples for Risk of Bias Tools 1: Cochrane Collboration
- Examples for Risk of Bias Tools 2: SYRCLE's RoB Tool
- Examples of Risk of Bias Tools 3: National Institute for Environmental Health Sciences (NIEHS) - OHAT
- Quality Assessment in Evidence-Based Toxicology
- Evidence-Based Toxicology (EBT) and Evidence-Based Toxicology Collaboration (EBTC)
- Zebrafish Systematic Review
- Supporting reading
- Supporting reading
- Practice Quiz 4
- Quality Assurance, Good Practices, and Validation
- Welcome to Module 5
- The Concepts of Quality Assurance (QA) and Good Practice (GP)
- Good Practice
- Quality Assurance
- Importance of GP and QA in EBT
- The Evolution of Validation of Alternative Methods
- The Traditional Validation Process
- Example of a Validation Study: Skin Irritation
- Developments in the Validation Area
- Validation and Tox-21c/EBT
- Supporting reading
- Supporting reading
- Practice Quiz 5
- Biometrical Tools & Future Perspectives
- Welcome to Module 6
- Why We Need Biometry/Statistics in Evidence-Based Toxicology
- Statistics and Bioinformatics Applied in Evidence-Based Approaches I
- Statistics and Bioinformatics Applied in Evidence-Based Approaches II
- Risk and Bias and Its Impact on Evidence-Based Approaches
- Evidence-Based Is a More Rigorous Scientific Approach to Anything
- The Reproducibility Crisis in Science
- Where Is Evidence-Based Toxicology (EBT) and What Are The Next Steps?
- Supporting reading
- Practice quiz 6
- Final exam
- Summative Assessment - Systematic Review Assignment
- Systematic Review Assignment Instructions
- Systematic Review Assignment Results
Summary of User Reviews
Discover how toxicology is being used to solve key environmental and public health issues in the 21st century. This highly informative course on evidence-based toxicology received great reviews from learners worldwide.Key Aspect Users Liked About This Course
Many users found the course content highly informative and useful.Pros from User Reviews
- The course covers a wide range of topics and provides a comprehensive understanding of the subject.
- The instructors are highly knowledgeable and provide excellent support to learners.
- The course is well-structured and easy to follow, with plenty of resources to aid learning.
- The course provides useful insights into real-world toxicology problems and how they are being addressed.
Cons from User Reviews
- Some learners found the course content too technical and difficult to understand.
- The course could benefit from more interactive elements, such as quizzes or assignments.
- Some learners found the course lacked practical applications and was too theoretical.
- The course may not be suitable for those without a background in science or toxicology.
- Some learners found the course pace too slow and repetitive.
Thomas Hartung
4.7 Raiting
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Welcome to the Evidence-based Toxicology (EBT) course. In medicine and healthcare, evidence-based medicine has revolutionized the way that information is evaluated transparently and objectively....
