Brief Introduction
Learn how scientists in drug development modify and test molecules to improve potency and reduce toxicity. Discover the criteria that regulatory agencies use to approve molecules that are shown to be both safe and effective as pharmaceuticals for the treatment and prevention of diseases.
Description
Drug discovery is a challenging field, but the pathway most drugs navigate from concept to market is predictable and based upon repeated experimentation. The process requires scientists with expertise in chemistry, biology, and medicine. This course focuses on four aspects of drug development.
- regulation - approval protocols for government regulatory agencies
- pharmacodynamics - how a drug affects the body
- pharmacokinetics - how a drug flows through the body
- lead discovery/optimization - the steps for finding and improving molecules as potential drugs
The course closes with two case studies of molecules that have advanced through the development process and into clinical trials.
Knowledge
- After completing this course, students will be able to...
- contrast the different steps of the drug discovery process,
- summarize the relationship between patents and generic drugs,
- interpret dose-response curves from the action of drugs on proteins,
- calculate drug-target binding energies from potency measures,
- describe factors that affect the flow of a drug through the body,
- predict structural changes in a molecule to influence half-life,
- priorize weakly active molecules as potential drug candidates,
- implement modifications to improve the properties of drug-like molecules, and
- assess literature reports of drug development programs.
Drug Discovery & Medicinal Chemistry
- 0.0
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Learn how scientists in drug development modify and test molecules to improve potency and reduce toxicity. The process requires scientists with expertise in chemistry, biology, and medicine....
Medicinal Chemistry: The Molecular Basis of Drug Discovery
- 0.0
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Gain a better understanding of the drug discovery process to learn how safe, effective drugs are developed and optimized. How to measure the activity of enzymes and receptors...
Nanotechnology and Nanosensors, Part1
- 4.6
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Nanotechnology and nanosensors are broad, interdisciplinary areas that encompass (bio)chemistry, physics, biology, materials science, electrical engineering and more. ---------------- COURSE OBJECTIVES...
Nanotechnology and Nanosensors, Part 2
- 4.8
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Learn about novel sensing tools that make use of nanotechnology to screen, detect and monitor various events in personal or professional life....
