Course Summary
Toxicology 21 is a course that will teach you about the potential health effects of chemicals and other substances. You'll learn how to identify toxic substances and how to prevent exposure to them.Key Learning Points
- Learn about the different types of toxic substances and how they can affect the body
- Understand the principles of toxicology and how they're used to evaluate exposure and risk
- Explore the latest research on toxic substances and how to prevent exposure
Related Topics for further study
Learning Outcomes
- Identify toxic substances and understand their potential health effects
- Evaluate exposure and risk using toxicology principles
- Implement prevention strategies to reduce exposure to toxic substances
Prerequisites or good to have knowledge before taking this course
- Basic knowledge of chemistry and biology
- Access to a computer and internet connection
Course Difficulty Level
IntermediateCourse Format
- Self-paced
- Online
- Video lectures
- Quizzes and assignments
Similar Courses
- Environmental Toxicology
- Introduction to Toxicology
Related Education Paths
Notable People in This Field
- Dr. Sandra Steingraber
- Dr. Tyrone Hayes
Related Books
Description
This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.
Outline
- Module 1
- Welcome to Module 1
- Course Introduction
- Introduction
- Center for Alternatives to Animal Testing
- Toxicology of the Fifteenth to Twentieth Centuries
- Toxicology for the Twenty-First Century
- Historical Perspective
- The First Report: Toxicity Testing for Assessment of Environmental Agents
- The Second Report: Toxicity Testing in the 21st Century: A Vision and A Strategy Vision and Its Components
- The Second Report: Toxicity Testing in the 21st Century: A vision and A Strategy Implementation
- useful links
- supporting reading material
- Supporting reading material
- Module 1 Quiz
- Module 2
- Welcome to Module 2
- Adverse Outcome Pathways (AOPs)
- Exposure-Based Chemical Prioritization
- ER Bioactivity Model
- US EPA Endocrine Disruptor Screening Program (EDSP)
- Modeling of Hazard and Organ Manifestation
- Building a Signature for Vascular Disruption
- Testing the Vascular Disruption Signature
- Virtual Tissue Model: Vascular Development
- Functional Vascular Development Assays
- Supporting Reading Material
- Useful links
- Supporting Reading Material
- Useful links
- Module 2 Quiz
- Module 3
- Welcome to Module 3
- Mechanistic Toxicology and Pathway Mapping at the Basics of 21st Century Toxicology
- The Concept of the Human Toxome Project
- Concept and Tool Devlopment
- Progress
- Conclusions and Prospectives
- Introduction - What Is a Pathway of Toxicity, and Why Do We Need Them?
- Omics Technologies and High-Throughput Data
- Interpreting Omics Data
- PoT Examples and Conclusions
- Pathways of Toxicity and Adverse Outcome Pathways (AOPs)
- Supporting reading materials
- Supporting reading material
- Module 3 Quiz
- Module 4
- The Need, and Opportunity, for a New Approach to Toxicology, Including Predictive Tools
- The Concept of Toxicological (Biological) Pathways, e.g., “Adverse Outcome Pathways,” Is the Basis of Predictive Toxicology
- Introduction to the OECD AOP Framework
- Building, Evaluating, and Using AOPs in Safety Decisions
- Online Tools Available to Everyone, Including an Online AOP Course
- Welcome to Module 4
- Introduction to Read-Across
- Good Read-Across Practice
- Supporting Read-Across with Biological Data
- Creating a Database of Toxicity
- Creating an Automated Tool for Read-Across
- Paradigm Shift in Toxicology
- 2D In Vitro Cell Culture
- 3D In Vitro Cell Cultures
- Organ-on-a-Chip
- Supporting reading material
- Supporting reading material
- Useful links
- Module 4 Quiz
- Mid-term exam
- Module 5
- Welcome to Module 5
- MicroRNA and Epigenetics
- Epigenetics and Environment
- MicroRNA: Biogenesis and Functions
- Role of MicroRNA in Development
- MicroRNA in Toxicology
- Supporting reading material
- Module 5 Quiz
- Module 6
- Welcome to Module
- Physiologically Based Biokinetic Modeling
- Application of QIVIVE to in Vitro Testing
- Challenges for Conducting QIVIVE
- Quantitative in Vitro to in Vivo Extrapolation
- Definition of Biometry/Biostatistics and Revisiting Some Statistical Basics
- Types of Tox21 Data and Data Mining of External Data Sources
- Bioinformatics Tools for the Interpretation of Tox21 Data
- Supporting reading material
- Supporting reading material
- Useful links
- Module 6 Quiz
- Module 7
- Welcome to Module 7
- Why Integrated Testing Strategies?
- What is an Integrated Testing Strategy?
- How to Compose Integrated Testing Strategies
- Strategies for Integrated Testing Strategies
- Quality Assurance of integrated Testing Strategies
- Legal Background
- Economic Background
- Tox-21c for Drug Safety
- Green Toxicology as Non-regulatory Tox-21c Approaches
- Conclusions and Prospects
- Supporting reading material
- Supporting reading material
- Module 7 Quiz
- Final Exam
Summary of User Reviews
Discover the world of toxicology with this comprehensive course on Coursera. Students have praised the course for its engaging content and helpful instructors. Gain a deep understanding of the effects of toxins on living organisms and the environment.Key Aspect Users Liked About This Course
The course instructors were found to be particularly helpful and knowledgeable.Pros from User Reviews
- Instructors are knowledgeable and engaging
- Content is comprehensive and informative
- Videos and lectures are well-produced
- Quizzes and assignments are challenging and thought-provoking
- Course is free to audit
Cons from User Reviews
- Some technical issues with video playback
- Course can be overwhelming for beginners
- Not enough interaction with other students
- No certification for auditing students
- Some students found the course material to be dry
Lena Smirnova
4.7 Raiting
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Archaeology is, among human sciences, the discipline with the strongest importance for the rediscovery, but also for the preservation and protection of cultural heritage, as Humankind’s universal patrimony....
Toxicology 21: Scientific Applications
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” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies....
