Course Summary
This course explores the genetic basis of diseases and the methods used to identify disease-causing genes. You will learn about genome sequencing, gene mapping, and the use of model organisms to study disease.Key Learning Points
- Understand the genetic basis of diseases and the methods used to identify disease-causing genes
- Learn about genome sequencing, gene mapping, and the use of model organisms to study disease
- Explore the ethical, legal, and social issues surrounding genetic testing and gene editing
Related Topics for further study
Learning Outcomes
- Understand the genetic basis of diseases and the methods used to identify disease-causing genes
- Explore the ethical, legal, and social issues surrounding genetic testing and gene editing
- Be able to critically evaluate scientific literature in the field of medical genetics
Prerequisites or good to have knowledge before taking this course
- Basic knowledge of genetics
- Familiarity with DNA sequencing and gene expression analysis
Course Difficulty Level
IntermediateCourse Format
- Self-paced
- Online
Similar Courses
- Genomics and Precision Medicine
- Molecular Biology and Genetic Engineering
Related Education Paths
Notable People in This Field
- Dr. Francis Collins
- Dr. Jennifer Doudna
Related Books
Description
Human genetics explores the genetically determined similarities and differences between human beings. This scientific discipline encompasses a variety of related fields such as molecular genetics, genomics, population genetics and medical genetics. Study of human genetics can help to find answers to questions regarding the inheritance and development of different human phenotypes. The field of medical genetics is quickly growing and dynamically developing thanks to the new technologies such as the next-generation sequencing.
Outline
- Introduction. Human genome
- From Disease to Genes and Back: Course Promo Video
- Course Introduction
- Anatomy of the Human Genome
- Identifying Functionally Important Elements in the Human Reference Genome
- Genetic Polymorphism
- Interrogating Genetic Variation
- Week 1 Conclusion
- Meet your Educators and Fellow Learners
- Course Navigation
- Typos in videos
- Recommended Pre-reading
- The Human Genome Project
- Recommended Pre-reading
- Recommended Pre-reading
- Recommended Pre-reading
- Glossary Week 1
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Introduction. Human Genome
- Populational genetics
- Introduction to Populational Genetics
- Hardy-Weinberg Equilibrium
- Linkage Disequilibrium
- Natural Selection
- Genetic Drift
- Genetic Structure
- Week 2 Conclusion
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Glossary Week 2
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Populational Genetics
- Mendelian disorders
- Introduction to Monogenic Disorders
- Linkage Analysis. Family Studies
- NGS for Studying Monogenic Disorders — Part I
- NGS for Studying Monogenic Disorders — Part II
- NGS for Studying Monogenic Disorders — Part III
- Week 3 Conclusion
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Mendelian disorders: discussion
- Glossary Week 3
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Mendelian Disorders
- Complex disorders
- From Linkage to Association Gene-Mapping
- Introduction to Genome-Wide Association Studies. Historical Overview
- GWAS Nowadays. Imputations
- 4.4. Analysis of Directly Genotyped and Imputed data. Significance of GWAS
- 4.5. Population Stratification and its Consequences
- 4.6. Analysis of Genetically Structured Populations
- 4.7. Meta-analysis of GWAS Results: Theory and Background
- 4.8. Quality Control of GWAS Array Data
- 4.9. Meta-analysis of GWAS Results: Practical Details
- Week 4 Conclusion
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Additional Materials
- Glossary Week 4
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Post-lecture Questions
- Pre-lecture Questions
- Post-lecture Questions
- Pre-lecture Questions
- Post-lecture Questions
- Pre-lecture Questions
- Post-lecture Questions
- Pre-lecture Questions
- Post-lecture Questions
- Pre-lecture Questions
- Quiz
- Complex disorders
- From variant to function. Application of the genomic findings
- Cystic Fibrosis — A Story of Human Genetics
- The Challenges of BRCA1/BRCA2 Testing
- Mendelian Tricks: Trinucleotide Repeat Expansions
- Glycans and Disease. The MODY 3 Story
- Identifying Causative Genes. Integration of the Genomic Data
- Multifactorial Disorders in Clinical Practice
- Week 5 Conclusion
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Recommended Pre-reading
- Additional Materials
- Additional Materials. Week 5
- Glossary Week 5
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Pre-lecture Questions
- Practice Quiz
- Weekly Quiz
- Final reflection
- Interviews with Michel Georges, Yurii Aulchenko and Gert Matthijs
Summary of User Reviews
The Disease Gene course on Coursera is highly rated by users. Many students found the course content and delivery to be engaging and informative.Key Aspect Users Liked About This Course
The course content was engaging and informative.Pros from User Reviews
- Comprehensive coverage of disease genes and their impact on health
- Interactive quizzes and assessments helped reinforce learning
- Instructors were knowledgeable and responsive to student questions
Cons from User Reviews
- Some students found the pacing of the course to be slow
- The course required a significant time commitment
- The technical aspects of the course (e.g. video quality) could be improved
Gert Matthijs
4.7 Raiting
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